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PGS (Preimplantation Genetic Screening)

PGS is a genetic screening test performed to check for the presence of any abnormal chromosome that functions as a carrier of any congenital disease. Rathimed Fertility Centre offers the most advanced screening test to ensure only the best and healthiest embryo is transferred and implanted into the uterine cavity for development. The PGS test removes the risk of passing inheriting congenital diseases within the family to next generations. The screening test analyzes all the 23 chromosomes present in an embryo cell for any chromosomal abnormality. An embryo that comes clean from a


screening test is used for transfer and implantation in the uterine cavity.

PGS Procedure

During the IVF procedure, the egg and sperms are mixed to fuse and fertilize into an embryo. The embryo rapidly multiples and reaches the multiple celled stage. Once the embryo is multi-celled, few sample cells are collected from the embryo through biopsy and the PGD test is conducted. The biopsy process does not harm the embryo and is performed in two ways:

  • A biopsy on 3rd day of fertilization performed on polar bodies of cleavage stage embryos, collecting a single cell from the embryo
  • A biopsy on 5th, 6th or 7th day at Trophectoderm stage, collecting a few cells each from the embryos

The specialist screens for any chromosomal abnormalities, extra copies of chromosomes, or missing chromosomes. The embryos are preserved till the results are generated. Once the results are confirmed, only the healthy embryos showing normal chromosome pairs are transferred into the uterine cavity for implantation. PGS test completely eliminates the risk of having a child carrying congenital diseases.

Who is a good candidate for PGD?

Any partner couples who have a genetic disorder including mosaicism of sex chromosomes, structural rearrangement and monogenic genetic diseases are suggested to have a pre implantation diagnosis test to ensure that the abnormality is not passed into next generation. Other circumstances that recommend a PGD test include:

  • Couples who are experiencing repeat pregnancy loss
  • Couples who already have one child with a congenital diseases
  • High maternal and paternal age
  • Male factor infertility
  • Repeated implantation failure

PGS was successfully used to screens a number of genetic disorders, including Duchenne muscular dystrophy, sickle cell anemia, leigh syndrome, retinoblastoma, heredity inclusions body myopathy, cardiac disorders and carriers of BRCA1 and helps identify abnormalities that can cause implantation failure during IVF.

Rathimed Fertility Centre offers different levels of PGS tests based on individual risk factors. There are two types of PGS test available at our centre:

  • Fluorescence In Situ Hybridization (FISH) –FISH genetic screening is performed to check for the presence of X chromosome linked disorders and genetic abnormalities. The screening prevents the passage of chromosome-linked abnormalities to the offspring.
  • Microarray Comparative Genomic Hybridization (Array CGH) – Array CGH is used for aneuploidy screening analyzing both X and Y chromosomes.

Rathimed Fertility Centre increases the likelihood of giving birth to a healthy child in conjunction with In-Vitro Fertilization to help choose the healthiest embryos for implantation and development. To know more about PGS test and your chances for conception, book an appointment now.


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